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Monitor Carefully (one)pentobarbital will minimize the extent or influence of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into a reduce in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, advance